Publications

Uppala S, Gamliel A, Harris T, Sosna J, Gomori JM, Jerschow A, and Katz-Brull R. (2019) 1H-decoupling and isotopic labeling for the measurement of the longitudinal relaxation time of hyperpolarized 13C-methylenes in choline analogs. Isr. J. Chem. In Press

 

Gamliel A, Uppala S, Sapir G, Harris T, Nardi-Schreiber A, Shaul D, Sosna J, Gomori JM, and Katz-Brull R. (2019) Hyperpolarized ]15N[nitrate as a potential long lived hyperpolarized contrast agent for MRI. J. Magn. Reson. 299: 188–195. DOI: 10.1016/j.jmr.2019.01.001

 

Lev-Cohain N, Sapir G, Harris T, Azar A, Gamliel A, Nardi-Schreiber A, Uppala S, Sosna J, Gomori JM, and Katz-Brull R (2019) Real-time ALT and LDH activities determined in viable precision-cut mouse liver slices using hyperpolarized [1-13C]pyruvate – implications for studies on biopsied liver tissues. NMR Biomed. 32:e4043. DOI:10.1002/nbm.4043

 

Harris T, Gamliel A, Sosna J, Gomori JM, and Katz-Brull R (2018) Impurities of [1-13C]pyruvic acid and a method to minimize their signals for hyperpolarized pyruvate metabolism studies. Appl. Magn. Reson. 49(10):1085–1098, DOI:10.1007/s00723-018-1030-1

 

Harris T, Azar A, Sapir G, Gamliel A, Nardi-Schreiber A, Sosna J, Gomori JM, and Katz-Brull R (2018) Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-13C]pyruvate. Sci. Rep. 8:9564, DOI:10.1038/s41598-018-27747-w

 

Harris T, Gamliel A, Uppala S, Nardi-Schreiber A, Sosna J, Gomori JM, and Katz-Brull R (2018) Long-lived 15N hyperpolarization and rapid relaxation as a potential basis for repeated first pass perfusion imaging – marked effects of deuteration and temperature. ChemPhysChem, 19: 2148– 2152, DOI: 10.1002/cphc.201800261

 

Hövener J-B, Pravdivtsev AN, Kidd B, Bowers CR, Glöggler S, Kovtunov KV, Plaumann M, Katz-Brull R, Buckenmaier K, Jerschow A, Reineri F, Theis T, Shchepin RV, Wagner S, Bhattacharya P, Zacharias NM, and Chekmenev EY (2017) Parahydrogen-based Hyperpolarization for Biomedicine. Angew. Chem. Int. Ed. 57: 11140–11162. DOI: 10.1002/anie.201711842

 

Nardi-Schreiber A, Sapir G, Gamliel A, Kakhlon O, Sosna J, Gomori JM, Meiner V, Lossos A, and Katz-Brull R (2017) Defective ATP breakdown activity related to an ENTPD1 gene mutation demonstrated using 31P NMR. Chem Commun 53: 9121 – 9124.

 

Nardi-Schreiber A, Gamliel A, Harris T, Sapir G, Sosna J, Gomori JM, and Katz-Brull R (2017) Biochemical phosphates observed using hyperpolarized 31P in physiological aqueous solutions. Nat Commun, 8(1): 341

 

Grigoletto J, Puka K, Gamliel A, Komisarov D, Katz-Brull R, Richter-Landsberg C, Sharon R (2017) Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. Acta Neuropathol Commun, 5(1):37.

 

Banne E, Meiner V, Shaag A, Katz-Brull R, Gamliel A, Korman S, Horowitz S, Plesser M, Frumkin A, Zilkha A, Kapuller V, Arbell D, Cohen E, Eventov-Friedman S. (2016) Transaldolase deficiency: A new case expands the phenotypic spectrum. J Inherit Metab Dis Rep, 26: 31–36

 

Martin M, Albensi B, Cross A, Katz-Brull R, Thiessen J, King S, Lin A. (2015) New concepts in magnetic resonance as applied to cellular and in vivo applications. Magn Reson Insights, 8(Suppl 1):49-52 (Editorial)

 

Gamliel A, Chendler N, Gomori JM, Sosna J, and Katz-Brull R (2015) The sensitivity of phosphocholine 13C chemical shifts to pH. Appl Magn Reson, 47(1): 111-120

 

Jupin M, Gamliel A, Hovav Y, Sosna J, Gomori JM, and Katz-Brull R (2015) Application of the steady-state variable nutation angle method for faster determinations of long T1s – an approach useful for the design of hyperpolarized MR molecular probes. Magn Reson Insights, 8(Suppl 1):41-47

 

Friesen-Waldner L, Wade T, Thind K, Chen AP, Gomori JM, Sosna J, McKenzie CA, and Katz-Brull R. (2015) Hyperpolarized choline as an MR imaging molecular probe: feasibility of imaging in a rat model. J Magn Reson Imaging, 41(4):917-23

 

Friesen–Waldner LJ, Wiens CN, Wade TP, Thind K, Sinclair KP, Hovav YGomori JM, Sosna J, McKenzie CA, and Katz-Brull R. (2014) Direct enzyme-substrate affinity determination by real-time hyperpolarized 13C-MRS. Chem Commun, 50 (89), 13801-13804

 

Allouche-Arnon H, Hovav Y, Friesen-Waldner L, Sosna J, Gomori JM, Vega S, and Katz-Brull R. (2014) Quantification of rate constants for successive enzymatic reactions with DNP hyperpolarized MR. NMR Biomed, 27 (6), 656-662

 

Allouche-Arnon H, Gamliel A, Sosna J, Gomori JM, Katz-Brull R. (2013) In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy. Chem Commun, 49 (63), 7076-7078

 

Allouche-Arnon H, Wade T, Friesen-Waldner L, Miller VN, Gomori JM, Katz-Brull R#, McKenzie CA#. (2013) In vivo magnetic resonance imaging of glucose – initial experience. Contrast Media Mol I, 8(1):72-82. # - Equal contribution.

 

Allouche-Arnon H, Lerche MH, Karlsson M, Lenkinski RE, and Katz-Brull R. (2011) Deuteration of a molecular probe for DNP hyperpolarization – a new approach and validation for choline chloride. Contrast Media Mol I, 6 (6): 499–506

 

Allouche-Arnon H, Gamliel A, Barzilay CM, Nalbandian R, Gomori JM, Karlsson M, Lerche MH, and Katz-Brull R. (2011) A hyperpolarized choline molecular probe for monitoring acetylcholine synthesis. Contrast Media Mol I, 6(3):139–147

 

Gamliel A, Allouche-Arnon H, Nalbandian R, Barzilay CM, Gomori JM, Katz-Brull R. (2010) An apparatus for production of isotopically and spin enriched hydrogen for induced polarization studies. Applied Magn Reson 39:329–345

 

Edvardson S, Korman SH, Livne A, Shaag A, Saada A, Nalbandian R, Allouche-Arnon H, Gomori JM, and Katz-Brull R. (2010) L-arginine:glycine amidinotransferase (AGAT) deficiency: clinical presentation and response to treatment in two patients with a novel mutation. Molec Genetics Metabol 101(2-3):228-32

 

Lima MA, Katz-Brull R, Lenkinski RE, Nunez R, Feinrider D, and Koralnik IJ. (2007) Remission of progressive multifocal leukoencephalopathy and primary central nervous system lymphoma in an HIV-infected patient. Eur J Neurol 14(6):598-602  

 

Katz-Brull R, Alsop DC, Marquis RP, and Lenkinski RE. (2006) Limits on activation induced temperature and metabolic changes in the human primary visual cortex. Magn Reson Med 56(2):348-355 

 

Katz-Brull R, Koudinov AR, and Degani H. (2005) Direct detection of brain acetylcholine synthesis by magnetic resonance spectroscopy. Brain Res 1048(1-2):202-210

 

Katz-Brull R, Rofsky NM, Morrin M, Pedrosa I, George DJ, Michaelson MD, Marquis RP, Maril M, Noguera C, and Lenkinski RE. (2005) Decrease in free cholesterol and fatty acids unsaturation in renal cell carcinoma, demonstrated by breath hold magnetic resonance spectroscopy. Am J Physiol-Renal 288(4):F637-641

 

Katz-Brull R, Lenkinski RE, Du Pasquier RA, and Koralnik IJ. (2004) Elevation of myo-Inositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology 63(5):897-900

 

Katz-Brull R and Lenkinski RE. (2004) Frame-by-frame PRESS 1H-MRS of the brain at 3T: The effects of physiological motion. Magn Reson Med 51:184-187

 

Katz-Brull R, Rofsky NM, and Lenkinski RE. (2003) Breathhold abdominal and thoracic proton magnetic resonance spectroscopy at 3T. Magn Reson Med 50:461-467

 

Katz-Brull R, Lavin PT, and Lenkinski RE. (2002) The clinical utility of proton MRS in characterizing breast lesions. JNCI-J Natl Cancer I (16):1197-1203. (Review and Meta-Analysis)

 

Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, and Degani H. (2002) Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res 62(7):1966-1970

 

Katz-Brull R, Koudinov A, and Degani H. (2002) Choline in the aging brain. Brain Res 951(2):158-165

 

Katz-Brull R, Margalit R, Degani H. (2001) Differential routing of choline in implanted breast cancer and normal organs. Magn Reson Med 46: 31-38

 

Katz-Brull R, Margalit R, Bendel P, Degani H. (1998) Choline metabolism in breast cancer; 2H, 13C & 31P NMR studies of cells and tumors. MAGMA Magn Reson Materials Physics Biol Med 6: 44-52

 

Katz-Brull R and Degani H. (1996) Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res 16: 1375-1380